Retinal neurodegeneration is predominantly reported as the apoptosis or impaired function
of the photoreceptors. Retinal degeneration is a major causative factor of irreversible vision …

Complement is an ancient and complex network of the immune system and, as such, it plays
vital physiological roles, but it is also involved in numerous pathological processes. The …

Atypical hemolytic uremic syndrome (aHUS) an important form of a thrombotic
microangiopathy (TMA) that can frequently lead to acute kidney injury (AKI). An important …

Background C3 glomerulopathy and idiopathic immunoglobulin-mediated
membranoproliferative GN (Ig-MPGN) are rare complement-mediated kidney diseases …

Genetic testing has uncovered rare variants in complement proteins associated with
thrombotic microangiopathy (TMA) and C3 glomerulopathy (C3G). Approximately 50% are …

Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy typically
characterized by anemia, thrombocytopenia, and end-organ injury. aHUS occurs due to …

Patients with paroxysmal nocturnal hemoglobinuria (PNH) are susceptible to complement-
mediated intravascular hemolysis and thrombosis. Factor H (FH) is the main regulator of the …

Background The dysfunction of complement factor H (CFH), the main soluble complement
negative regulator, potentiates various complement-induced renal injuries. However …

The complement system consists of three pathways (alternative, classical, and lectin) that
play a fundamental role in immunity and homeostasis. The multifunctional role of the …

The complement system is a critical innate immune defense mechanism that also facilitates
antigen recognition as well as antibody production through the adaptive immune response …