The activation of antigen receptors triggers two important signalling pathways originating
from phosphatidylinositol (4, 5)-bisphosphate [PtdIns (4, 5) P 2]. The first is phospholipase …

During hematopoiesis, stem cell proliferation is dependent on expression of the D-type
cyclins. However, little is known about how each cyclin D contributes to the development of …

PI3K plays key roles in cell growth, differentiation, and survival by generating the second
messenger phosphatidylinositol-(3, 4, 5)-trisphosphate (PIP3). PIP3 activates numerous …

B‐cell activating factor of the TNF family (BAFF) is critical for the survival and maturation of B
cells. The molecular mechanisms by which BAFF regulates the survival of developing B cells …

Abstract Cyclin D2 (CCND2, encoded by Ccnd2) plays an important role in the induction of
early-to-mid G1 phase transition and is required for granulosa cell proliferation during …

Abstract Phosphoinositide 3-kinase (PI3K) is a lipid kinase whose activation is crucial for
many biological functions in multiple cell types. One research area of particular interest for …

Cyclin-dependent kinases (CDKs) play a crucial role in regulation of the mammalian cell
cycle. CDK4 and CDK6 control the G1/S restriction checkpoint through their ability to …

Abstract BH3‐only Bcl‐2 homologs are key regulators of the intrinsic apoptotic pathway. In
particular, Bim, is critical for mediating apoptosis of hematopoietic cells including B cells …

Multiple myeloma (MM) is a clinically and genetically heterogenous cancer where tumour
cells have dysregulated expression of a D-type cyclin, often in association with a recurrent …

Phosphoinositide kinase (PI3K) is activated by various receptors on lymphocytes and
regulates development, activation, and tolerance. Genetic ablation of PI3K function in T cells …