The hyperbolic form of the power-duration relationship is rigorous and highly conserved
across species, forms of exercise and individual muscles/muscle groups. For modalities …

In most daily activities related to work or leisure, the energy for muscle work substantially
comes from oxidative metabolism. Functional limitations or impairments of this metabolism …

Background: Heart failure with preserved ejection fraction (HFpEF) is a common syndrome
with a pressing shortage of therapies. Exercise intolerance is a cardinal symptom of HFpEF …

It is increasingly recognized that obesity is a risk factor for microvascular disease, involving
both structural and functional changes in the microvasculature. This review aims to describe …

Chronic heart failure (CHF) impairs critical structural and functional components of the O2
transport pathway resulting in exercise intolerance and, consequently, reduced quality of …

The physiological determinants of high-intensity exercise tolerance are important for both
elite human performance and morbidity, mortality and disease in clinical settings. The …

The hallmark symptom of chronic heart failure (HF) is severe exercise intolerance. Impaired
perfusive and diffusive O2 transport are two of the major determinants of reduced physical …

Three sentinel parameters of aerobic performance are the maximal oxygen uptake (), critical
power (CP) and speed of the kinetics following exercise onset. Of these, the latter is …

Methods Twelve healthy participants performed four exhaustive severe-intensity trials for the
determination of CT, and four 30-min trials in close proximity to CT (one or two SE above or …

V̇o2 max during whole body exercise is presumably constrained by oxygen delivery to
mitochondria rather than by mitochondria's ability to consume oxygen. Humans and animals …