Orbitofrontal and prelimbic cortices serve complementary roles in adapting reward seeking to learned anxiety
Background Anxiety is a common symptom of several mental health disorders and adversely
affects motivated behaviors. Anxiety can emerge from associating risk of future harm while …
affects motivated behaviors. Anxiety can emerge from associating risk of future harm while …
Delay of punishment highlights differential vulnerability to developing addiction-like behavior toward sweet food
M Solinas, V Lardeux, PM Leblanc… - Translational …, 2024 - nature.com
Resistance to punishment is commonly used to measure the difficulty in refraining from
rewarding activities when negative consequences ensue, which is a hallmark of addictive …
rewarding activities when negative consequences ensue, which is a hallmark of addictive …
Medial prefrontal cortex suppresses reward-seeking behavior with risk of punishment by reducing sensitivity to reward
M Nishio, M Kondo, E Yoshida… - Frontiers in Neuroscience, 2024 - frontiersin.org
Reward-seeking behavior is frequently associated with risk of punishment. There are two
types of punishment: positive punishment, which is defined as addition of an aversive …
types of punishment: positive punishment, which is defined as addition of an aversive …
Punishment Risk Task: Monitoring anxiogenic states during goal directed actions in mice
Canonical preclinical studies of anxiety-related behavioral states have been critical to
developing mechanistic insights and therapeutics for neuropsychiatric disorders. Most of …
developing mechanistic insights and therapeutics for neuropsychiatric disorders. Most of …
Reward and punishment contingency shifting reveals distinct roles for VTA dopamine and GABA neurons in behavioral flexibility
MJ Lefner, B Moghaddam - bioRxiv, 2024 - biorxiv.org
In dynamic environments where stimuli predicting rewarding or aversive outcomes
unexpectedly change, it is critical to flexibly update behavior while preserving recollection of …
unexpectedly change, it is critical to flexibly update behavior while preserving recollection of …
Complementary roles of orbitofrontal and prelimbic cortices in adaptation of reward motivated actions to learned anxiety
DS Jacobs, AP Bogachuk, B Moghaddam - bioRxiv, 2023 - biorxiv.org
Background Anxiety is a common symptom of several mental health disorders and adversely
affects motivated behaviors. Anxiety can emerge from associating risk of future harm while …
affects motivated behaviors. Anxiety can emerge from associating risk of future harm while …