Extending the viability of acute brain slices
The lifespan of an acute brain slice is approximately 6–12 hours, limiting potential
experimentation time. We have designed a new recovery incubation system capable of …
experimentation time. We have designed a new recovery incubation system capable of …
Structural and functional changes of deep layer pyramidal neurons surrounding microelectrode arrays implanted in rat motor cortex
BA Gregory, CH Thompson, JW Salatino, MJ Railing… - Acta Biomaterialia, 2023 - Elsevier
Devices capable of recording or stimulating neuronal signals have created new
opportunities to understand normal physiology and treat sources of pathology in the brain …
opportunities to understand normal physiology and treat sources of pathology in the brain …
Stability of neocortical synapses across sleep and wake states during the critical period in rats
BA Cary, GG Turrigiano - Elife, 2021 - elifesciences.org
Sleep is important for brain plasticity, but its exact function remains mysterious. An influential
but controversial idea is that a crucial function of sleep is to drive widespread downscaling of …
but controversial idea is that a crucial function of sleep is to drive widespread downscaling of …
An aerator for brain slice experiments in individual cell culture plate wells
DM Dorris, CA Hauser, CE Minnehan… - Journal of neuroscience …, 2014 - Elsevier
Background Ex vivo acute living brain slices are a broadly employed and powerful
experimental preparation. Most new technology regarding this tissue has involved the …
experimental preparation. Most new technology regarding this tissue has involved the …
Differential effects of sodium channel blockers on in vitro induced epileptiform activities
Antiepileptic drugs act on voltage gated sodium channels in many different ways: rufinamide
is thought to influence the fast inactivation, so its anticonvulsant action could be similar to …
is thought to influence the fast inactivation, so its anticonvulsant action could be similar to …
Braincubator: An incubation system to extend brain slice lifespan for use in neurophysiology
In vitro brain slice preparations are instrumental in developing our understanding of the
nervous system. However, the current lifespan of an acute brain slice is limited to …
nervous system. However, the current lifespan of an acute brain slice is limited to …
[HTML][HTML] Analysis of acute brain slices by electron microscopy: A correlative light–electron microscopy workflow based on Tokuyasu cryo-sectioning
CL Fonta, A Leis, C Mathisen, DS Bouvier… - Journal of structural …, 2015 - Elsevier
Acute brain slices are slices of brain tissue that are kept vital in vitro for further recordings
and analyses. This tool is of major importance in neurobiology and allows the study of brain …
and analyses. This tool is of major importance in neurobiology and allows the study of brain …
Brain slice viability determined under normoxic and oxidative stress conditions: involvement of slice quantity in the medium
Objective: In vitro acute adult brain slice methods are instruments in developing our
knowledge of the nervous system. Optimization of this method for obtaining high-quality …
knowledge of the nervous system. Optimization of this method for obtaining high-quality …
Antisense oligodeoxynucleotide perfusion blocks gene expression of synaptic plasticity-related proteins without inducing compensation in hippocampal slices
The elucidation of the molecular mechanisms of long-term synaptic plasticity has been
hindered by both the compensation that can occur after chronic loss of the core plasticity …
hindered by both the compensation that can occur after chronic loss of the core plasticity …
Stability of cortical synapses across sleep and wake
BA Cary, GG Turrigiano - BioRxiv, 2019 - biorxiv.org
Sleep is widely believed to be an essential regulator of synaptic plasticity, but there is
disagreement on whether it primarily enables correlation-based plasticity mechanisms such …
disagreement on whether it primarily enables correlation-based plasticity mechanisms such …