Cells of unicellular and multicellular eukaryotes can respond to certain environmental cues
by arresting the cell cycle and entering a reversible state of quiescence. Quiescent cells do …

Diverse signaling cues and attendant proteins work together during organogenesis,
including craniofacial development. Lip and palate formation starts as early as the fourth …

Calvarial bone is one of the most complex sequences of developmental events in
embryology, featuring a uniquely transient, pluripotent stem cell-like population known as …

Background Endothelial injury caused by Type 2 diabetes mellitus (T2DM) is considered as
a mainstay in the pathophysiology of diabetic vascular complications (DVCs). However, the …

E3 ubiquitin ligases, an important part of ubiquitin proteasome system, catalyze the covalent
binding of ubiquitin to target substrates, which plays a role in protein ubiquitination and …

The mammalian skull vault is a highly regulated structure that evolutionally protects brain
growth during vertebrate development. It consists of several membrane bones with different …

Acute lymphoblastic leukemia (ALL) has been a huge threat for people's health and finding
effective target therapy is urgent and important. WWP2, as one of E3 ubiquitin ligase, is …

The growth of a metazoan body relies on a series of highly coordinated cell-fate decisions
by stem cells which can undergo self-renewal, reversibly enter a quiescent state, or …

Bone health requires adequate bone mass, which is maintained by a critical balance
between bone resorption and formation. In our study, we identified beraprost as a pivotal …

Simple Summary During embryonic development, cells proliferate and move to form
structures essential to each organ. As these dynamic processes occur cells must form …