COVID-19 is a highly transmissible disease caused by severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2), affects 226 countries and continents, and has resulted in> 6.2 …

microRNAs (miRs) are emerging as attractive therapeutic targets because of their small size,
specific targetability, and critical role in disease pathogenesis. However,< 20 miR targeting …

Inflammatory reactions in the graft have a pivotal influence on acute as well as long-term
graft function. The main reasons for an inflammatory reaction of the graft tissue are rejection …

Optimizing kidney preservation is a primary issue in transplantation, particularly in relation to
new donor sources, such as expanded criteria donors (ECDs) and donation after cardiac …

Antisense oligonucleotides (As-ODNs) are single stranded, synthetically prepared strands of
deoxynucleotide sequences, usually 18–21 nucleotides in length, complementary to the …

An improved understanding of disease pathogenesis leads to identification of novel
therapeutic targets. From a pharmacologic point of view, these can be addressed by small …

Background: Many experimental and clinical studies have focused on the antisense
strategy. In this context phosphorothioate oligonucleotides are compounds addressed to …

The blood levels of microRNA-122 (miR-122) is associated with the severity of
cardiovascular disorders, and targeting it with efficient and safer miR inhibitors could be a …

Small interfering RNA (siRNA) has established its reputation in the field of tissue
engineering owing to its ability to silence the proteins that inhibit tissue regeneration. siRNA …

Experimental and clinical evidence has accumulated in support of the notion that oxidative
injuries to allografts induce an adaptive alloimmune response which leads to acute …