Chemists, like artists, are able to construct new threedimensional objects, molecules and
materials that exist only in the mind of a person. I became interested in creating novel …

Recognition of the DNA minor groove by pyrrole-imidazole polyamides - ScienceDirect Skip
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DNA has for many years been the traditional target for chemotherapeutic intervention1 in
human cancers, especially for those where high proliferation rates of some tumour cell types …

The design of synthetic ligands that read the information stored in the DNA double helix has
been a long-standing goal at the interface of chemistry and biology,,,,. Cell-permeable small …

SMALL molecules that specifically bind with high affinity to any predetermined DNA
sequence in the human genome would be useful tools in molecular biology and potentially …

The solid phase synthesis of sequence specific DNA binding polyamides containing N-
methylimidazole (Im) and N-methylpyrrole (Py) amino acids is described. Two monomer …

Polyamide dimers containing three types of aromatic rings—pyrrole, imidazole, and
hydroxypyrrole—afford a small-molecule recognition code that discriminates among all four …

A Fluorescent Intercalator Displacement Assay for Establishing DNA Binding Selectivity and
Affinity | Accounts of Chemical Research ACS ACS Publications C&EN CAS Find my institution …

The crystal structure of a complex of human TATA-binding protein with TATA-sequence DNA
has been solved, complementing earlier TBP/DNA analyses fromSaccharomyces …

Sequence-specific DNA-binding small molecules that can permeate cells could potentially
regulate transcription of specific genes. Simple pairing rules for the minor groove of the …