CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular
signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed …

While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …

Alzheimer's disease (AD) is a progressive and neurodegenerative disorder of the cortex and
hippocampus, which eventually leads to cognitive impairment. Although the etiology of AD …

The morbidity and mortality of autoimmune diseases (Ads) have been increasing worldwide,
and the identification of novel therapeutic strategies for prevention and treatment is urgently …

Microglia are the primary cells that exert immune function in the central nervous system
(CNS), and accumulating evidence suggests that microglia act as key players in the initiation …

Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have
traditionally been linked with calorie restriction and aging in mammals. These proteins also …

Whole grains are a pivotal food category for the human diet and represent an invaluable
source of carbohydrates, proteins, fibers, phytocompunds, minerals, and vitamins. Many …

Background: Current interventions for major depressive disorder (MDD) are suboptimal, and
only one third respond to them on initial treatment. Neuroplasticity theories are the basis for …

Glia cells are mediators as well as targets of the chronic inflammatory process in the central
nervous system of multiple sclerosis (MS) patients. They are involved in the control of …

Sirtuins are evolutionarily conserved proteins that use nicotinamide adenine dinucleotide
(NAD+) as a co-substrate in their enzymatic reactions. There are seven proteins (SIRT1-7) in …