Viruses as transneuronal tracers for defining neural circuits

AD Loewy - Neuroscience & Biobehavioral Reviews, 1998 - Elsevier
LOEWY, AD Viruses as transneuronal tracers for defining neural circuits. NEUROSCI
BIOBEHAV REV 22 (6) 679–684, 1998.—Live viruses can be used as tools to label chains of …

Transneuronal labeling of CNS neuropeptide and monoamine neurons after pseudorabies virus injections into the stellate ganglion

ASP Jansen, MW Wessendorf, AD Loewy - Brain research, 1995 - Elsevier
The viral transneuronal labeling method was used in combination with
immunohistochemical procedures to identify CNS neuropeptide and monoamine neurons …

CNS sites involved in sympathetic and parasympathetic control of the pancreas: a viral tracing study

ASP Jansen, JL Hoffman, AD Loewy - Brain research, 1997 - Elsevier
The viral transneuronal tracing method was used to identify the CNS cell groups that
regulate the parasympathetic and sympathetic outflow systems of the pancreas …

Role of the virion host shutoff (vhs) of herpes simplex virus type 1 in latency and pathogenesis

LI Strelow, DA Leib - Journal of virology, 1995 - Am Soc Microbiol
The herpes simplex virus type 1 (HSV-1) UL41 gene product, virion host shutoff (vhs), has
homologs among five alphaherpesviruses (HSV-1, HSV-2, pseudorabies virus, varicella …

Amplicon-based herpes simplex virus vectors

DY Ho - Methods in Cell Biology, 1994 - Elsevier
Publisher Summary The wide host range of herpes simplex virus type 1 (HSV-I), both in vivo
and in vitro, and the relative ease of its genetic manipulation have made it an attractive …

The virion host shutoff protein of herpes simplex virus 1 blocks the replication-independent activation of NF-κB in dendritic cells in the absence of type I interferon …

CR Cotter, W Kim, ML Nguyen, JS Yount… - Journal of …, 2011 - Am Soc Microbiol
Immune evasion is a defining feature of the virus-host relationship. During infection, herpes
simplex virus type 1 (HSV-1) utilizes multiple proteins to manipulate the host immune …

Herpes simplex virus type 1 ICP0 protein does not accumulate in the nucleus of primary neurons in culture

XP Chen, J Li, M Mata, J Goss, D Wolfe… - Journal of …, 2000 - Am Soc Microbiol
ABSTRACT Infected-cell protein 0 (ICP0), the product of the herpes simplex virus (HSV)
immediate-early (IE) α0 gene, is a promiscuous transactivator of viral early (E) and late (L) …

Herpes simplex virus gene expression in neurons: viral DNA synthesis is a critical regulatory event in the branch point between the lytic and latent pathways

PF Nichol, JY Chang, EM Johnson Jr… - Journal of virology, 1996 - Am Soc Microbiol
Herpes simplex virus establishes a latent infection in peripheral neurons. We examined viral
gene expression in rat peripheral neurons in vitro and determined that viral gene expression …

The virion host shut-off (vhs) protein blocks a TLR-independent pathway of herpes simplex virus type 1 recognition in human and mouse dendritic cells

CR Cotter, ML Nguyen, JS Yount, CB López… - PLoS …, 2010 - journals.plos.org
Molecular pathways underlying the activation of dendritic cells (DCs) in response to Herpes
Simplex Virus type 1 (HSV-1) are poorly understood. Removal of the HSV virion host shut-off …

Deletion of the virion host shut-off gene enhances neuronal-selective transgene expression from an HSV vector lacking functional IE genes

Y Miyagawa, G Verlengia, B Reinhart, F Han… - … Therapy Methods & …, 2017 - cell.com
The ability of herpes simplex virus (HSV) to establish lifelong latency in neurons suggests
that HSV-derived vectors hold promise for gene delivery to the nervous system. However …