[HTML][HTML] SCD1 is the critical signaling hub to mediate metabolic diseases: Mechanism and the development of its inhibitors

Q Sun, X Xing, H Wang, K Wan, R Fan, C Liu… - Biomedicine & …, 2024 - Elsevier
Metabolic diseases, featured with dysregulated energy homeostasis, have become major
global health challenges. Patients with metabolic diseases have high probability to manifest …

Sprayable hydrogel dressing accelerates wound healing with combined reactive oxygen species-scavenging and antibacterial abilities

H Cheng, Z Shi, K Yue, X Huang, Y Xu, C Gao, Z Yao… - Acta biomaterialia, 2021 - Elsevier
Wound management poses a considerable economic burden on the global healthcare
system, considering the impacts of wound infection, delayed healing and scar formation. To …

Adipose tissue plasticity and the pleiotropic roles of BMP signaling

S Qian, Y Tang, QQ Tang - Journal of Biological Chemistry, 2021 - ASBMB
Adipose tissues, including white, beige, and brown adipose tissue, have evolved to be
highly dynamic organs. Adipose tissues undergo profound changes during development …

Branched-chain fatty acids alter the expression of genes responsible for lipid synthesis and inflammation in human adipose cells

A Czumaj, T Śledziński, A Mika - Nutrients, 2022 - mdpi.com
Recently, we have demonstrated a decreased level of iso-branched-chain fatty acids (iso-
BCFAs) in patients with excessive weight. However, it is still unclear whether BCFAs may …

Early-life exposure to bisphenol A induces dysregulation of lipid homeostasis by the upregulation of SCD1 in male mice

R Fang, S Yang, X Gu, C Li, N Bi, HL Wang - Environmental Pollution, 2022 - Elsevier
Abstract Exposure of Bisphenol A (BPA) is closely associated with an increased prevalence
of obesity-related metabolic syndrome. However, the potential mechanism of BPA-induced …

Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins

R Nanduri, T Furusawa, A Lobanov, B He, C Xie… - Nature …, 2022 - nature.com
White adipose tissue browning is a key metabolic process controlled by epigenetic factors
that facilitate changes in gene expression leading to altered cell identity. We find that male …

Endothelial cell-derived stem cell factor promotes lipid accumulation through c-Kit-mediated increase of lipogenic enzymes in brown adipocytes

HJ Lee, J Lee, MJ Yang, YC Kim, SP Hong… - Nature …, 2023 - nature.com
Active thermogenesis in the brown adipose tissue (BAT) facilitating the utilization of lipids
and glucose is critical for maintaining body temperature and reducing metabolic diseases …

Knockout of stearoyl-CoA desaturase 1 decreased milk fat and unsaturated fatty acid contents of the goat model generated by CRISPR/Cas9

H Tian, H Niu, J Luo, W Yao, X Chen, J Wu… - Journal of Agricultural …, 2022 - ACS Publications
Goat milk contains a rich source of nutrients, especially unsaturated fatty acids. However, the
regulatory mechanism of milk fat and fatty acid synthesis remains unclear. Stearoyl-CoA …

Depot-dependent impact of time-restricted feeding on adipose tissue metabolism in high fat diet-induced obese male mice

T Bushman, TY Lin, X Chen - Nutrients, 2023 - mdpi.com
Time-restricted feeding (TRF) is known to be an effective strategy for weight loss and
metabolic health. TRF's effect on metabolism is complex and likely acts on various pathways …

Intermittent fasting resolves dyslipidemia and atherogenesis in apolipoprotein E-deficient mice in a diet-dependent manner, irrespective of sex

J Mérian, L Ghezali, C Trenteseaux, T Duparc… - Cells, 2023 - mdpi.com
In humans and animal models, intermittent fasting (IF) interventions promote body weight
loss, improve metabolic health, and are thought to lower cardiovascular disease risk …