Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus
Research in cellular mechanotransduction often focuses on how extracellular physical
forces are converted into chemical signals at the cell surface. However, mechanical forces …
forces are converted into chemical signals at the cell surface. However, mechanical forces …
The nuclear envelope
MW Hetzer - Cold Spring Harbor perspectives in biology, 2010 - cshperspectives.cshlp.org
The nuclear envelope (NE) is a highly regulated membrane barrier that separates the
nucleus from the cytoplasm in eukaryotic cells. It contains a large number of different …
nucleus from the cytoplasm in eukaryotic cells. It contains a large number of different …
The modular nature of genetic diseases
M Oti, HG Brunner - Clinical genetics, 2007 - Wiley Online Library
Evidence from many sources suggests that similar phenotypes are begotten by functionally
related genes. This is most obvious in the case of genetically heterogeneous diseases such …
related genes. This is most obvious in the case of genetically heterogeneous diseases such …
An absence of cutaneous neurofibromas associated with a 3-bp inframe deletion in exon 17 of the NF1 gene (c. 2970-2972 delAAT): evidence of a clinically significant …
M Upadhyaya, SM Huson, M Davies, N Thomas… - The American Journal of …, 2007 - cell.com
Neurofibromatosis type 1 (NF1) is characterized by café-au-lait spots, skinfold freckling, and
cutaneous neurofibromas. No obvious relationships between small mutations (< 20 bp) of …
cutaneous neurofibromas. No obvious relationships between small mutations (< 20 bp) of …
Human matrix metalloproteinases: an ubiquitarian class of enzymes involved in several pathological processes
D Sbardella, GF Fasciglione, M Gioia, C Ciaccio… - Molecular aspects of …, 2012 - Elsevier
Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …
Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle …
Rationale: Vascular calcification is prevalent in the aging population, yet little is known of the
mechanisms driving age-associated vascular smooth muscle cell (VSMC) phenotypic …
mechanisms driving age-associated vascular smooth muscle cell (VSMC) phenotypic …
Intermediate filament scaffolds fulfill mechanical, organizational, and signaling functions in the cytoplasm
S Kim, PA Coulombe - Genes & development, 2007 - genesdev.cshlp.org
Intermediate filaments (IFs) are cytoskeletal polymers whose protein constituents are
encoded by a large family of differentially expressed genes. Owing in part to their properties …
encoded by a large family of differentially expressed genes. Owing in part to their properties …
Nuclear lamins: key regulators of nuclear structure and activities
M Prokocimer, M Davidovich… - Journal of cellular …, 2009 - Wiley Online Library
• The lamin molecule‐Domain organization of lamins‐Lamins are divided to type A and type
B‐Post‐translational processing of lamin molecules‐Lamin molecules in evolution• The …
B‐Post‐translational processing of lamin molecules‐Lamin molecules in evolution• The …
Structural basis for lamin assembly at the molecular level
Nuclear structure and function are governed by lamins, which are intermediate filaments that
mostly consist of α-helices. Different lamin assembly models have been proposed based on …
mostly consist of α-helices. Different lamin assembly models have been proposed based on …
Global loss of a nuclear lamina component, lamin A/C, and LINC complex components SUN 1, SUN 2, and nesprin‐2 in breast cancer
A Matsumoto, M Hieda, Y Yokoyama… - Cancer …, 2015 - Wiley Online Library
Cancer cells exhibit a variety of features indicative of atypical nuclei. However, the molecular
mechanisms underlying these phenomena remain to be elucidated. The linker of …
mechanisms underlying these phenomena remain to be elucidated. The linker of …