The tumor microenvironment (TME) is jointly constructed by a variety of cell types, including
tumor cells, immune cells, fibroblasts, and epithelial cells, among others. The cells within the …

The adaptation of natural killer (NK) cells to conditions in the microenvironment of tumors is
deeply affected by their metabolic activity, itself a result of nutrient availability and the …

Promising progress has been made in adoptive transfer of allogeneic natural killer (NK) cells
to treat relapsed or refractory acute myeloid leukemia (AML). In this regard, chimeric antigen …

Natural killer (NK) cells recognize virally infected cells and tumors. NK cell function depends
on balanced signaling from activating receptors, recognizing products from tumors or …

NK cells utilize a large array of receptors to screen their surroundings for aberrant or virus‐
infected cells. Given the vast diversity of receptors expressed on NK cells we seek to identify …

Oncolytic virotherapy is emerging as a promising therapeutic avenue for cancer treatment,
harnessing both innate and tumor-specific immune responses for targeted tumor elimination …

Background Ex vivo cultivation is a promising strategy for increasing the number of NK cells
and enhancing their antitumor activity prior to clinical application. Recent studies show that …

Herpes simplex virus type 1 (HSV‐1) infects and persists in most of the human population.
Interleukin‐15 (IL‐15) has an important role in the activation of cell‐mediated immune …

Simple Summary Conventional natural killer (NK)-based anticancer immunotherapy has a
limitation: a culture period of approximately 2 weeks is required to increase the number and …

Signaling via inhibitory KIR/Ly49 receptors preserves natural killer (NK) cell self-tolerance
but also conveys NK cell reactivity towards MHC class-I low target cells in an education …