Vascular cognitive impairment (VCI) and depression frequently coexist in geriatric
populations and reciprocally increase disease risks. We assert that a shared pre-disease …

In inflammatory bowel diseases (IBD), the most promising therapies targeting cytokines or
immune cell trafficking demonstrate around 40% efficacy. As IBD is a multifactorial …

Abstract Early Warning Signals (EWS) have generated much excitement for their potential to
anticipate transitions in various systems, ranging from climate change in ecology to disease …

Real-world non-autonomous systems are open, out-of-equilibrium systems that evolve in
and are driven by temporally varying environments. Such systems can show multiple …

Organismal health and survival depend on the ability to mount an effective immune
response against infection. Yet immune defence may be energy-demanding, resulting in …

中医学使用阴平阳秘的相对平衡状态界定人的健康, 即健康是人体这个开放复杂巨系统整体动态
平衡的稳态. 稳态失衡则进入狭义的未病状态, 邪正相争, 存在向愈与向疾的两种演化趋势 …

Complex spatio-temporal systems like lakes, forests and climate systems exhibit alternative
stable states. In such systems, as the threshold value of the driver is crossed, the system …

Abrupt shifts between alternative regimes occur in complex systems, from cell regulation to
brain functions to ecosystems. Several model-free early warning signals (EWS) have been …

Despite intensive investigations numerous diseases remain etiologically puzzling and
recalcitrant to treatments. A hypothesis is proposed here assuming that these difficulties are …

Detection of the tipping point of metastasis of non-small cell lung carcinoma is crucial so that
it does not lead to irreversible damage. In contrast to the single biomarker approach …