Current update on intrinsic and acquired colistin resistance mechanisms in bacteria

FA Gogry, MT Siddiqui, I Sultan, QMR Haq - Frontiers in medicine, 2021 - frontiersin.org
Colistin regained global interest as a consequence of the rising prevalence of multidrug-
resistant Gram-negative Enterobacteriaceae. In parallel, colistin-resistant bacteria emerged …

Bacterial heterogeneity and antibiotic survival: understanding and combatting persistence and heteroresistance

L Dewachter, M Fauvart, J Michiels - Molecular cell, 2019 - cell.com
For decades, mankind has dominated the battle against bacteria, yet the tide is slowly
turning. Our antibacterial strategies are becoming less effective, allowing bacteria to get the …

A naturally inspired antibiotic to target multidrug-resistant pathogens

Z Wang, B Koirala, Y Hernandez, M Zimmerman… - Nature, 2022 - nature.com
Gram-negative bacteria are responsible for an increasing number of deaths caused by
antibiotic-resistant infections,. The bacterial natural product colistin is considered the last …

Antibiotic combinations that exploit heteroresistance to multiple drugs effectively control infection

VI Band, DA Hufnagel, S Jaggavarapu… - Nature …, 2019 - nature.com
Antibiotic-resistant bacteria are a significant threat to human health, with one estimate
suggesting they will cause 10 million worldwide deaths per year by 2050, surpassing deaths …

Periodontitis and cardiometabolic disorders: The role of lipopolysaccharide and endotoxemia

PJ Pussinen, E Kopra, M Pietiäinen… - Periodontology …, 2022 - Wiley Online Library
Lipopolysaccharide is a virulence factor of gram‐negative bacteria with a crucial importance
to the bacterial surface integrity. From the host's perspective, lipopolysaccharide plays a role …

Resolving colistin resistance and heteroresistance in Enterobacter species

SP Doijad, N Gisch, R Frantz, BV Kumbhar… - Nature …, 2023 - nature.com
Species within the Enterobacter cloacae complex (ECC) include globally important
nosocomial pathogens. A three-year study of ECC in Germany identified Enterobacter …

The role of antimicrobial peptides as antimicrobial and antibiofilm agents in tackling the silent pandemic of antimicrobial resistance

BS Lopes, A Hanafiah, R Nachimuthu, S Muthupandian… - Molecules, 2022 - mdpi.com
Just over a million people died globally in 2019 due to antibiotic resistance caused by
ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella …

Antimicrobial resistance in enteric bacteria: current state and next-generation solutions

MJ Wallace, SRS Fishbein, G Dantas - Gut microbes, 2020 - Taylor & Francis
Antimicrobial resistance is one of the largest threats to global health and imposes
substantial burdens in terms of morbidity, mortality, and economic costs. The gut is a key …

Antibiotic Heteroresistance in Klebsiella pneumoniae

K Stojowska-Swędrzyńska, A Łupkowska… - International journal of …, 2021 - mdpi.com
Klebsiella pneumoniae is one of the most common pathogens responsible for infections,
including pneumonia, urinary tract infections, and bacteremias. The increasing prevalence …

The burden of hospital acquired infections and antimicrobial resistance

MK Abban, EA Ayerakwa, L Mosi, A Isawumi - Heliyon, 2023 - cell.com
The burden of Hospital care-associated infections (HCAIs) is becoming a global concern.
This is compounded by the emergence of virulent and high-risk bacterial strains such as" …