Epidermal growth factor receptor cell proliferation signaling pathways
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation
E Mladenov, S Magin, A Soni, G Iliakis - Seminars in cancer biology, 2016 - Elsevier
Eukaryotic cells respond to DNA damage by activating a comprehensive network of
biochemical pathways that enable damage recognition and initiate responses leading to …
biochemical pathways that enable damage recognition and initiate responses leading to …
Blocking c-Met–mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors
Y Du, H Yamaguchi, Y Wei, JL Hsu, HL Wang… - Nature medicine, 2016 - nature.com
Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as promising
therapeutics for many diseases, including cancer, in clinical trials. One PARP inhibitor …
therapeutics for many diseases, including cancer, in clinical trials. One PARP inhibitor …
ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB
Actively transcribed regions of the genome are protected by transcription-coupled DNA
repair mechanisms, including transcription-coupled homologous recombination (TC-HR) …
repair mechanisms, including transcription-coupled homologous recombination (TC-HR) …
Targeting DNA double-strand break repair pathways to improve radiotherapy response
M Toulany - Genes, 2019 - mdpi.com
More than half of cancer patients receive radiotherapy as a part of their cancer treatment.
DNA double-strand breaks (DSBs) are considered as the most lethal form of DNA damage …
DNA double-strand breaks (DSBs) are considered as the most lethal form of DNA damage …
Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways
X Meng, Y Zhao, B Han, C Zha, Y Zhang, Z Li… - Nature …, 2020 - nature.com
Activation of receptor tyrosine kinase (RTK) protein is frequently observed in malignant
progression of gliomas. In this study, the crosstalk activation of epidermal growth factor …
progression of gliomas. In this study, the crosstalk activation of epidermal growth factor …
Regulation of the DNA damage response by DNA-PKcs inhibitory phosphorylation of ATM
Ataxia-telangiectasia mutated (ATM) regulates the DNA damage response as well as DNA
double-strand break repair through homologous recombination. Here we show that ATM is …
double-strand break repair through homologous recombination. Here we show that ATM is …
FOXM1 Variant Contributes to Gefitinib Resistance via Activating Wnt/β-Catenin Signal Pathway in Patients with Non–Small Cell Lung Cancer
S Guan, X Chen, Y Chen, W Xie, H Liang, X Zhu… - Clinical Cancer …, 2022 - AACR
Purpose: Although gefitinib prolonged the progression-free survival (PFS) of patients with
non–small cell lung cancer (NSCLC), unpredictable resistance limited its clinical efficacy …
non–small cell lung cancer (NSCLC), unpredictable resistance limited its clinical efficacy …
Targeting AKT/PKB to improve treatment outcomes for solid tumors
The serine/threonine kinase AKT, also known as protein kinase B (PKB), is the major
substrate to phosphoinositide 3-kinase (PI3K) and consists of three paralogs: AKT1 (PKBα) …
substrate to phosphoinositide 3-kinase (PI3K) and consists of three paralogs: AKT1 (PKBα) …
Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases
Intracellular localization has been reported for over three‐quarters of receptor tyrosine
kinase (RTK) families in response to environmental stimuli. Internalized RTK may bind to …
kinase (RTK) families in response to environmental stimuli. Internalized RTK may bind to …