Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression

GA Stamatiades, UB Kaiser - Molecular and cellular endocrinology, 2018 - Elsevier
The precise orchestration of hormonal regulation at all levels of the hypothalamic-pituitary-
gonadal axis is essential for normal reproductive function and fertility. The pulsatile secretion …

Molecular regulation of follicle-stimulating hormone synthesis, secretion and action

N Das, TR Kumar - Journal of molecular endocrinology, 2018 - jme.bioscientifica.com
Follicle-stimulating hormone (FSH) plays fundamental roles in male and female fertility. FSH
is a heterodimeric glycoprotein expressed by gonadotrophs in the anterior pituitary. The …

Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor

Z Naor - Frontiers in neuroendocrinology, 2009 - Elsevier
Gonadotropin-releasing hormone (GnRH) is the first key hormone of reproduction. GnRH
analogs are extensively used in in vitro fertilization, and treatment of sex hormone …

GnRH pulse frequency-dependent differential regulation of LH and FSH gene expression

IR Thompson, UB Kaiser - Molecular and cellular endocrinology, 2014 - Elsevier
The pituitary gonadotropin hormones, FSH and LH, are essential for fertility. Containing an
identical α-subunit (CGA), they are comprised of unique β-subunits, FSHβ and LHβ …

Hormones in synergy: regulation of the pituitary gonadotropin genes

VG Thackray, PL Mellon, D Coss - Molecular and cellular endocrinology, 2010 - Elsevier
The precise interplay of hormonal influences that governs gonadotropin hormone production
by the pituitary includes endocrine, paracrine and autocrine actions of hypothalamic …

[HTML][HTML] Mechanisms of FSH synthesis: what we know, what we don't, and why you should care

DJ Bernard, J Fortin, Y Wang, P Lamba - Fertility and sterility, 2010 - Elsevier
The pituitary gonadotropin hormones, FSH and LH, are key regulators of reproductive
physiology. Though the two hormones are produced by the same cell type, often in response …

Actions and roles of FSH in germinative cells

K Recchia, AS Jorge, LVF Pessôa, RC Botigelli… - International Journal of …, 2021 - mdpi.com
Follicle stimulating hormone (FSH) is produced by the pituitary gland in a coordinated
hypothalamic–pituitary–gonadal (HPG) axis event, plays important roles in reproduction and …

A new pathway in the control of the initiation of puberty: the MKRN3 gene

AP Abreu, DB Macedo, VN Brito… - Journal of …, 2015 - jme.bioscientifica.com
Follicle-stimulating hormone (FSH) plays fundamental roles in male and female fertility. FSH
is a heterodimeric glycoprotein expressed by gonadotrophs in the anterior pituitary. The …

Molecular mechanisms of gonadotropin-releasing hormone signaling: integrating cyclic nucleotides into the network

RM Perrett, CA McArdle - Frontiers in endocrinology, 2013 - frontiersin.org
Gonadotropin-releasing hormone (GnRH) is the primary regulator of mammalian
reproductive function in both males and females. It acts via G-protein coupled receptors on …

Gonadotropin-inhibitory hormone inhibits GnRH-induced gonadotropin subunit gene transcriptions by inhibiting AC/cAMP/PKA-dependent ERK pathway in LβT2 cells

YL Son, T Ubuka, RP Millar, H Kanasaki… - Endocrinology, 2012 - academic.oup.com
A neuropeptide that directly inhibits gonadotropin secretion from the pituitary was
discovered in quail and named gonadotropin-inhibitory hormone (GnIH). The presence and …