Panic disorder

PP Roy-Byrne, MG Craske, MB Stein - The Lancet, 2006 - thelancet.com
Panic disorder is a common mental disorder that affects up to 5% of the population at some
point in life. It is often disabling, especially when complicated by agoraphobia, and is …

Genetics of anxiety disorders: Genetic epidemiological and molecular studies in humans

M Shimada‐Sugimoto, T Otowa… - Psychiatry and clinical …, 2015 - Wiley Online Library
This review provides a broad overview of the state of research in the genetics of anxiety
disorders (AD). Genetic epidemiological studies report a moderate level of familial …

The molecular genetic architecture of human personality: beyond self-report questionnaires

RP Ebstein - Molecular psychiatry, 2006 - nature.com
Molecular genetic studies of personality began with two high impact papers in 1996 that
showed provisional associations between the dopamine DRD4 exon III repeat region and …

The epidemiology of DSM-IV panic disorder and agoraphobia in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions

BF Grant, DS Hasin, FS Stinson… - Journal of Clinical …, 2006 - psychiatrist.com
Objective: To present nationally representative data on the prevalence, correlates, and
comorbidity of DSM-IV panic disorder (PAN), including the differentiation between panic with …

What is the genetic relationship between anxiety and depression?

JM Hettema - American journal of medical genetics part C …, 2008 - Wiley Online Library
Anxiety and depression share a long, close history in psychiatric nosology and treatment.
The anxiety disorders, individually and as a group, exhibit remarkably high rates of …

TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies

A Erhardt, L Czibere, D Roeske, S Lucae… - Molecular …, 2011 - nature.com
The lifetime prevalence of panic disorder (PD) is up to 4% worldwide and there is substantial
evidence that genetic factors contribute to the development of PD. Single-nucleotide …

Meta‐analysis of COMT val158met in panic disorder: Ethnic heterogeneity and gender specificity

K Domschke, J Deckert… - American Journal of …, 2007 - Wiley Online Library
There is strong evidence for a genetic contribution to the pathogenesis of panic disorder,
with the functional catechol‐O‐methyltransferase (COMT) val158met polymorphism having …

Significant linkage on chromosome 10p in families with bulimia nervosa

CM Bulik, B Devlin, SA Bacanu, L Thornton… - The American Journal of …, 2003 - cell.com
Bulimia nervosa (BN) is strongly familial, and additive genetic effects appear to contribute
substantially to the observed familiality. In turn, behavioral components of BN, such as self …

Imaging genetics of anxiety disorders

K Domschke, U Dannlowski - Neuroimage, 2010 - Elsevier
Anxiety disorders are frequent and burdensome psychiatric diseases. Despite their
moderate to strong heritabilities, the search for candidate genes has been limited by …

Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism

J Fullerton, M Cubin, H Tiwari, C Wang… - The American Journal of …, 2003 - cell.com
Several theoretical studies have suggested that large samples of randomly ascertained
siblings can be used to ascertain phenotypically extreme individuals and thereby increase …