Chemokines are the largest family of cytokines in human immunophysiology. These proteins
are defined by four invariant cysteines and are categorized based on the sequence around …

Biased signaling of G protein-coupled receptors describes an ability of different ligands that
preferentially activate an alternative downstream signaling pathway. In this work, we …

Atherosclerosis is characterized by chronic inflammation of the arterial wall due to
chemokine-driven mononuclear cell recruitment,,,. Activated platelets can synergize with …

The human chemokine system comprises 19 seven-transmembrane helix (7TM) receptors
and 45 endogenous chemokines that often interact with each other in a promiscuous …

The reported structures of many CC chemokines show a conserved dimer interface along
their N-terminal region, raising the possibility that the quaternary arrangement of these small …

Chemokines are small proteins best known for their role in controlling the migration of
diverse cells, particularly leukocytes. Upon binding to their G-protein-coupled receptors on …

NMR spectra of human lymphotactin (hLtn), obtained under various solution conditions,
have revealed that the protein undergoes a major conformational rearrangement dependent …

Lymphotactin, the sole identified member of the C class of chemokines, specifically attracts T
lymphocytes and natural killer cells. This 93-residue protein lacks 2 of the 4 conserved …

Chemokines are best known as signaling proteins in the immune system. Recently however,
a large number of human chemokines have been shown to exert direct antimicrobial activity …

Chemokines adopt a conserved tertiary structure stabilized by two disulfide bridges and
direct the migration of leukocytes. Lymphotactin (Ltn) is a unique chemokine in that it …