Animal models are essential to gain a deeper understanding of the pathophysiology
associated with traumatic brain injury (TBI). Rodent models of TBI have proven highly …

BACKGROUND Treatment of acute trauma coagulopathy has shifted toward rapid
replacement of coagulation factors with frozen plasma (FP). There are logistic difficulties in …

BACKGROUND Administration of human mesenchymal stem cell (MSC)–derived exosomes
can enhance neurorestoration in models of traumatic brain injury (TBI) and hemorrhagic …

Introduction Head injury and exsanguination are the leading causes of death in trauma
patients. Hemorrhagic shock triggers systemic endothelial glycocalyx breakdown, potentially …

ABSTRACT Purpose/Aim: Animal models of traumatic brain injury (TBI) provide powerful
tools to study TBI in a controlled, rigorous and cost-efficient manner. The mostly used …

Traumatic brain injury (TBI)‐induced coagulopathy has long been recognized as a
significant risk for poor outcomes in patients with TBI, but its pathogenesis remains poorly …

Background Circulating cell-free DNA (cfDNA) is not found in healthy subjects, but is readily
detected after thermal injury and may contribute to the risk of multiple organ failure. The …

We have shown previously that fresh frozen plasma (FFP) and lyophilized plasma (LP)
decrease brain lesion size and improve neurological recovery in a swine model of traumatic …

Traumatic brain injury (TBI) and severe blood loss (SBL) frequently co-occur in human
trauma, resulting in high levels of mortality and morbidity. Importantly, each of the individual …

Frontiers | Traumatic Brain Injury—A Review of Intravenous Fluid Therapy Skip to main
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