The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …

The immunological hallmarks of sepsis include the inflammation-mediated cytokine storm,
apoptosis-driven lymphopenia, and prolonged immunoparalysis. Although early clinical …

INTRODUCTION The COVID-19 pandemic revealed enhanced vulnerability of the elderly
and chronically ill to adverse outcomes upon severe acute respiratory syndrome coronavirus …

Sepsis remains a major cause of death in the United States and worldwide, and costs
associated with treating septic patients place a large burden on the healthcare industry …

Laboratory mice comprise an expeditious model for preclinical vaccine testing; however,
vaccine immunogenicity in these models often inadequately translates to humans …

Opportunistic fungal infections have high mortality in patients with severe immune
dysfunction. Growing evidence suggests that the immune environment of invasive fungal …

Colorectal cancer (CRC) is a common and deadly disease. Unfortunately, immune
checkpoint inhibitors (ICIs) fail to elicit effective anti-tumour responses in the vast majority of …

Animals harbor diverse communities of microbes within their gastrointestinal tracts.
Phylogenetic relationship, diet, gut morphology, host physiology, and ecology all influence …

Just as the gut microbiota (GM) is now recognized as an integral mediator of environmental
influences on human physiology, susceptibility to disease, and response to pharmacological …

Microbial exposure during development can elicit long-lasting effects on the health of an
individual. However, how microbial exposure in early life leads to permanent changes in the …