The ability to design efficient enzymes from scratch would have a profound effect on
chemistry, biotechnology and medicine. Rapid progress in protein engineering over the past …

Biocatalysis harnesses enzymes to make valuable products. This green technology is used
in countless applications from bench scale to industrial production and allows practitioners …

The case for a renewed focus on Nature in drug discovery is reviewed; not in terms of
natural product screening, but how and why biomimetic molecules, especially those …

Designing efficient enzymes is a formidable challenge at the forefront of modern
biocatalysis. Here, we review recent developments in the field and illustrate how the …

Over 20 years ago, the pyrrolysine encoding translation system was discovered in specific
archaea. Our Review provides an overview of how the once obscure pyrrolysyl-tRNA …

In recent years, powerful genetic code reprogramming methods have emerged that allow
new functional components to be embedded into proteins as noncanonical amino acid …

The engineering of natural enzymes has led to the availability of a broad range of
biocatalysts that can be used for the sustainable manufacturing of a variety of chemicals and …

Since its discovery in the late 1960s, the Morita–Baylis–Hillman (MBH) reaction has
remained a powerful carbon–carbon σ-bond-forming transformation, producing small …

Biocatalysis is currently undergoing a profound transformation. The field moves from relying
on nature's chemical logic to a discipline that exploits generic activation modes, allowing for …

Enzymes are versatile and efficient biological catalysts that drive numerous cellular
processes, motivating the development of enzyme design approaches to tailor catalysts for …