Emerging roles for polycomb-group proteins in stem cells and cancer
Polycomb-group (PcG) complexes are multiprotein, evolutionarily conserved epigenetic
machineries that regulate stem cell fate decisions and development, and are also implicated …
machineries that regulate stem cell fate decisions and development, and are also implicated …
Polycomb proteins as organizers of 3D genome architecture in embryonic stem cells
T Pachano, G Crispatzu… - Briefings in Functional …, 2019 - academic.oup.com
Polycomb group proteins (PcGs) control the epigenetic and transcriptional state of
developmental genes and regulatory elements during mammalian embryogenesis …
developmental genes and regulatory elements during mammalian embryogenesis …
PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments
X-chromosome inactivation triggers fusion of A/B compartments to inactive X (Xi)-specific
structures known as S1 and S2 compartments. SMCHD1 then merges S1/S2s to form the Xi …
structures known as S1 and S2 compartments. SMCHD1 then merges S1/S2s to form the Xi …
Tunable, division-independent control of gene activation timing by a polycomb switch
During development, progenitors often differentiate many cell generations after receiving
signals. These delays must be robust yet tunable for precise population size control …
signals. These delays must be robust yet tunable for precise population size control …
Chromatin state switching in a polymer model with mark-conformation coupling
K Adachi, K Kawaguchi - Physical Review E, 2019 - APS
We investigate the phase transition properties of the polymer-Potts model, a chain
composed of monomers with magnetic degrees of freedom, with the motivation to study the …
composed of monomers with magnetic degrees of freedom, with the motivation to study the …
Cohesin disrupts polycomb-dependent chromosome interactions
How chromosome organisation is related to genome function remains poorly understood.
Cohesin, loop-extrusion, and CTCF have been proposed to create structures called …
Cohesin, loop-extrusion, and CTCF have been proposed to create structures called …
Orphan CpG islands boost the regulatory activity of poised enhancers and dictate the responsiveness of their target genes
T Pachano, V Sánchez-Gaya, M Mariner-Faulí, T Ealo… - biorxiv, 2020 - biorxiv.org
ARTICLE CpG islands (CGIs) represent a distinctive and widespread genetic feature of
vertebrate genomes, being associated with∼ 70% of all annotated gene promoters. CGIs …
vertebrate genomes, being associated with∼ 70% of all annotated gene promoters. CGIs …
Temporal scaling in developmental gene networks by epigenetic timing control
During development, progenitors follow defined temporal schedules for differentiation, to
form organs and body plans with precise sizes and proportions. Across diverse contexts …
form organs and body plans with precise sizes and proportions. Across diverse contexts …