According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …

The emergence of drug resistance is the most substantial challenge to the effectiveness of
anticancer therapies. Orthogonal approaches have revealed that a subset of cells, known as …

Although melanoma is notorious for its high degree of heterogeneity and plasticity,, the
origin and magnitude of cell-state diversity remains poorly understood. Equally, it is unclear …

How cancer cells escape immune surveillance and resist immune checkpoint blockade
(ICB) remains to be fully elucidated. By screening candidate genes frequently gained in …

The cell-autonomous balance of immune-inhibitory and-stimulatory signals is a critical
process in cancer immune evasion. Using patient-derived co-cultures, humanized mouse …

Human tumors are intricate ecosystems composed of diverse genetic clones and malignant
cell states that evolve in a complex tumor micro-environment. Single-cell RNA-sequencing …

Immune checkpoint blockade (ICB) approaches have changed the therapeutic landscape for
many tumor types. However, half of cutaneous squamous cell carcinoma (cSCC) patients …

Despite the remarkable clinical success of immunotherapies in a subset of cancer patients,
many fail to respond to treatment and exhibit resistance. Here, we found that genetic or …

Cells, as the fundamental units of life, contain multidimensional spatiotemporal information.
Single-cell RNA sequencing (scRNA-seq) is revolutionizing biomedical science by …

Cancer cellular heterogeneity and therapy resistance arise substantially from metabolic and
transcriptional adaptations, but how these are interconnected is poorly understood. Here, we …