D Shi, L Caldovic, M Tuchman - Biology, 2018 - mdpi.com
Carbamyl phosphate (CP) is well-known as an essential intermediate of pyrimidine and arginine/urea biosynthesis. Chemically, CP can be easily synthesized from dihydrogen …
Aquifex aeolicus is a deep-branching hyperthermophilic chemoautotrophic bacterium restricted to hydrothermal vents and hot springs. These characteristics make it an excellent …
C Purcarea, A Ahuja, T Lu, L Kovari, HI Guy… - Journal of Biological …, 2003 - ASBMB
Aquifex aeolicus, an organism that flourishes at 95° C, is one of the most thermophilic eubacteria thus far described. The A. aeolicus pyrB gene encoding aspartate …
C Auger, ND Appanna, A Alhasawi, VD Appanna - EuPA Open Proteomics, 2015 - Elsevier
Metabolism is the consortium of reactions within a cell which directs a variety of processes including energy synthesis, signalling and the behaviour of a biological system. Metabolic …
A Ahuja, C Purcarea, R Ebert, S Sadecki, HI Guy… - Journal of Biological …, 2004 - ASBMB
Dihydroorotase (DHOase) catalyzes the reversible condensation of carbamoyl aspartate to form dihydroorotate in de novo pyrimidine biosynthesis. The enzyme from Aquifex aeolicus …
N Glansdorff, Y Xu - Amino acid biosynthesis~ pathways, regulation and …, 2006 - Springer
A vast number of prokaryotic and eukaryotic microorganisms can synthesize arginine de novo from glutamate. The first committed step of this pathway is acetylation of l-glutamate at …
PD Martin, C Purcarea, P Zhang, A Vaishnav… - Journal of molecular …, 2005 - Elsevier
Dihydroorotases (EC 3.5. 2.3) catalyze the reversible cyclization of carbamoyl aspartate to form dihydroorotate in de novo pyrimidine biosynthesis. The X-ray structures of Aquifex …
Life is based on two aspects: matter and a non-material, electrical component. In a dynamic system of reciprocal causality, matter and the so-called bioelectricity interact with one …
As glutamate and ammonia play a pivotal role in nitrogen homeostasis, their production is mediated by various enzymes that are widespread in living organisms. Here, we report on …