Liquid–liquid phase separation (LLPS) of proteins and other biomolecules play a critical role
in the organization of extracellular materials and membrane‐less compartmentalization of …

The homeostasis of extremophiles is one that is a diamond hidden in the rough. The way
extremophiles adapt to their extreme environments gives a clue into the true extent of what is …

The accurate and reliable prediction of protein–ligand binding affinities can play a central
role in the drug discovery process as well as in personalized medicine. Of considerable …

The race to meet the challenges of the global pandemic has served as a reminder that the
existing drug discovery process is expensive, inefficient and slow. There is a major …

We subject a series of five protein–ligand systems which contain important SARS-CoV-2
targets, 3-chymotrypsin-like protease (3CLPro), papain-like protease, and adenosine ribose …

Cellulases have been used to extract bioactive ingredients from medical plants; however,
the poor enzymatic properties of current cellulases significantly limit their application. Two …

Free energy calculations for protein–ligand complexes have become widespread in recent
years owing to several conceptual, methodological and technological advances. Central …

Laccase is a blue enzyme with a remarkable ability to eliminate environmental pollutants.
The use of the eco-friendly enzyme for removing ecological contaminants is extensive. In …

Cyclodextrins (CDs) are well-known carriers for encapsulating hydrophobic molecules,
while among cannabinoids, cannabidiol (CBD) has attracted considerable attention due to …

The hot springs are populated by mesophilic, thermotolerant, and hyperthermophilic
bacteria. These populations are diverse, and some of them show combinations of other …