Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

Simple Summary Despite recent therapeutic advances against cancer, many patients do not
respond well or respond poorly, to treatment and develop resistance to more than one anti …

The traditional classification of lung cancer into small cell lung cancer and non‐small cell
lung cancer (NSCLC) has been transformed with the increased understanding of the …

Abstract The phosphoinositide 3-kinase (PI3K) pathway is a key signal transduction system
that links oncogenes and multiple receptor classes to many essential cellular functions, and …

There are ample genetic and laboratory studies that suggest the PI3K–Akt pathway is vital to
the growth and survival of cancer cells. Inhibitors targeting this pathway are entering the …

The phosphatidylinositol 3-kinase (PI3K) signaling axis impacts on cancer cell growth,
survival, motility, and metabolism. This pathway is activated by several different mechanisms …

Abstract Phosphatidylinositol 3-kinases (PI3Ks) evolved from a single enzyme that regulates
vesicle trafficking in unicellular eukaryotes into a family of enzymes that regulate cellular …

Gastric cancer imposes a considerable health burden around the globe despite its declining
incidence. The disease is often diagnosed in advanced stages and is associated with a poor …

Abstract Phosphatidylinositol-3-kinase (PI3K) is a lipid kinase and generates
phosphatidylinositol-3, 4, 5-trisphosphate (PI (3, 4, 5) P3). PI (3, 4, 5) P3 is a second …

Abstract AKT/PKB (protein kinase B) kinases mediate signaling pathways downstream of
activated tyrosine kinases and phosphatidylinositol 3-kinase. AKT kinases regulate diverse …