Leishmaniasis is a neglected infectious disease caused by several different species of
protozoan parasites of the genus Leishmania. Current strategies to control this disease are …

Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an essential
role in many cellular processes including cell cycle control, cell survival, hormone and other …

Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments
due to intrinsic drug resistance. These complex communities of multiple cell types form on …

The evolution of drug resistance has a profound impact on human health. Candida glabrata
is a leading human fungal pathogen that can rapidly evolve resistance to echinocandins …

Parasitic diseases cause significant global morbidity and mortality, particularly in
underdeveloped regions of the world. Malaria alone causes∼ 800 000 deaths each year …

Histone deacetylase (HDAC) enzymes work together with histone acetyltransferases (HATs)
to reversibly acetylate both histone and non-histone proteins. As a result, these enzymes are …

Covering: 2005 to 2013In this review recent progress in the development of heat shock
proteins (Hsp90) in oncogenesis is illuminated. Particular emphasis is put on inhibitors such …

This Letter presents a search for exotic decays of the Higgs boson to a pair of new (pseudo)
scalar particles, H→ aa, where the a particle has a mass in the range 20–60 GeV, and …

The molecular chaperone Hsp90 regulates the folding of diverse signal transducers in all
eukaryotes, profoundly affecting cellular circuitry. In fungi, Hsp90 influences development …

Central to Hsp90's biological function is its ability to interconvert between various
conformational states. Drug targeting of Hsp90's regulatory mechanisms, including its …