The glycome describes the complete repertoire of glycoconjugates composed of
carbohydrate chains, or glycans, that are covalently linked to lipid or protein molecules …

While HIV-1 infection of target cells with cell-free viral particles has been largely
documented, intercellular transmission through direct cell-to-cell contact may be a …

Glycosylation-mediated post-translational modification is critical for regulating many
fundamental processes like cell division, differentiation, immune response, and cell-to-cell …

The development of antiretroviral drugs (ARVs) was a great milestone in the management of
HIV infection. ARVs suppress viral activity in the host cell, thus minimizing injury to the cells …

HIV-1 has evolved mechanisms to evade host cell immune responses and persist for lifelong
infection. Latent cellular reservoirs are responsible for this persistence of HIV-1 despite the …

Background HIV associated neurocognitive disorders cause significant morbidity and
mortality despite the advent of highly active antiretroviral therapy. A deeper understanding of …

So far, only two retroviruses, human immunodeficiency virus (HIV)(type 1 and 2) and human
T-cell lymphotropic virus type 1 (HTLV-1), have been recognized as pathogenic for humans …

Chimeric Antigen Receptor (CAR) T cell therapy has proven to be an effective strategy
against hematological malignancies but persistence and activity against solid tumors must …

Natural killer (NK) cells are innate cytolytic effectors that target HIV-infected CD4+ T cells. In
conjunction with antibodies recognizing the HIV envelope, NK cells also eliminate HIV …

Viruses are obligate intracellular parasites that utilize cellular machinery for many aspects of
their replication cycles. Enveloped viruses generally rely upon host vesicular trafficking …