Creatine (Cr) is a ubiquitous molecule that is synthesized mainly in the liver, kidneys, and
pancreas. Most of the Cr pool is found in tissues with high-energy demands. Cr enters target …

Background Bipolar disorder phenomenologically is a biphasic disorder of energy
availability; increased in mania and decreased in depression. In consort, there is …

The voltage-dependent anion channel (VDAC) is a β-barrel membrane protein located in the
outer mitochondrial membrane (OMM). VDAC has two conductance states: an open anion …

Regulation of mitochondrial outer membrane (MOM) permeability has dual importance: in
normal metabolite and energy exchange between mitochondria and cytoplasm, and thus in …

Despite extensive research, the regulation of mitochondrial function is still not understood
completely. Ample evidence shows that cytosolic Ca2+ has a strategic task in co-ordinating …

There is an increasing body of evidence for local circuits of ATP generation and
consumption that are largely independent of global cellular ATP levels. These are mostly …

As the powerhouse of the cells, mitochondria play a very important role in ensuring that cells
continue to function. Mitochondrial dysfunction is one of the main factors contributing to the …

Physiological role of creatine (Cr) became first evident in the experiments of Belitzer and
Tsybakova in 1939, who showed that oxygen consumption in a well-washed skeletal muscle …

This review describes the recent experimental data on the importance of the VDAC–
cytoskeleton interactions in determining the mechanisms of energy and metabolite transfer …

The aim of this review is to analyze the results of experimental research of mechanisms of
regulation of mitochondrial respiration in cardiac and skeletal muscle cells in vivo obtained …