Tumor necrosis factor (TNF), initially reported to induce tumor cell apoptosis and cachexia, is
now considered a central mediator of a broad range of biological activities from cell …

Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine that becomes elevated in chronic
inflammatory states such as hypertension and diabetes and has been found to mediate both …

Angiotensin II–induced hypertension is associated with an increase in T-cell production of
interleukin-17A (IL-17A). Recently, we reported that IL-17A−/− mice exhibit blunted …

A recent genome-wide association study identified a locus on chromosome 16 in the
promoter region of the uromodulin (UMOD) gene that is associated with hypertension. Here …

The protean properties of 20-hydroxyeicosatetraenoic acid (HETE), vasoactivity,
mitogenicity, and modulation of transport in key nephron segments, serve as the basis for …

We studied hydroxyeicosatetraenoic acid (HETE) release in response to ANG II from
preglomerular microvessels (PGMVs), the vascular segment governing changes in renal …

Rapid DNA fragmentation from hypoxia along the thick ascending limb of rat kidneys.
Extensive DNA fragmentation, a marker for programmed cell death, was selectively and …

The effects of angiotensin II (ANG II) on tumor necrosis factor-α (TNF) production were
determined in freshly isolated tubules from the medullary thick ascending limb (MTAL). ANG …

The thick ascending limb plays a key role in maintaining water and electrolyte balance. The
importance of this segment in regulating blood pressure is evidenced by the effect of loop …

TNF-α (tumor necrosis factor-alpha) is the best known as a proinflammatory cytokine; yet,
this cytokine also has important immunomodulatory and regulatory functions. As the effects …