This article reviews findings up to the end of 1997 about the inducible transcription factors
(ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A …

beta-Amyloid precursor protein (beta-APP), the source of the fibrillogenic amyloid beta-
peptide (A beta) that accumulates in the brain of victims of Alzheimer's disease, is a …

Oxidative stress is believed to play important roles in neuronal cell death associated with
many different neurodegenerative conditions (eg, Alzheimer's disease, Parkinson's disease …

Given the critical role of mitogen-activated protein kinase (MAPK) pathways in regulating
cellular processes that are affected in Alzheimer's disease (AD), the importance of MAPKs in …

Evidence implicating the β-amyloid protein (Aβ) in the pathogenesis of Alzheimer's disease
has steadily accumulated. However, the mechanism by which Aβ causes dementia is …

Apoptosis is now recognized as a normal feature in the development of the nervous system
and may also play a role in neurodegenerative diseases and aging. This phenomenon has …

Axon interruption elicits a complex neuronal response that leaves neurons poised
precariously between death and regeneration. The signals underlying this dichotomy are not …

Previous studies have shown that β-amyloid (Aβ) peptides are neurotoxic. Recent data
suggest that neurons undergoing Aβ-induced cell death exhibit characteristics that …

Apoptosis is a process of active cell death, distinct from necrosis and characterized by
specific morphological and biochemical features. Although the acute hepatotoxic effects of …

As aged population dramatically increases in these decades, efforts should be made on the
intervention for curing age-associated neurodegenerative diseases such as Alzheimer's …