From demyelination to remyelination: the road toward therapies for spinal cord injury

F Papastefanaki, R Matsas - Glia, 2015 - Wiley Online Library
Myelin integrity is crucial for central nervous system (CNS) physiology while its preservation
and regeneration after spinal cord injury (SCI) is key to functional restoration. Disturbance of …

Small-molecule based musculoskeletal regenerative engineering

KWH Lo, T Jiang, KA Gagnon, C Nelson… - Trends in …, 2014 - cell.com
Clinicians and scientists working in the field of regenerative engineering are actively
investigating a wide range of methods to promote musculoskeletal tissue regeneration …

Polycaprolactone/polysialic acid hybrid, multifunctional nanofiber scaffolds for treatment of spinal cord injury

S Zhang, XJ Wang, WS Li, XL Xu, JB Hu, XQ Kang, J Qi… - Acta biomaterialia, 2018 - Elsevier
Scaffold-based tissue engineering is widely used for spinal cord injury (SCI) treatment by
creating supporting and guiding neuronal tissue regeneration. However, how to enhance …

Biomaterial-based regenerative therapeutic strategies for spinal cord injury

K Chen, W Yu, G Zheng, Z Xu, C Yang, Y Wang… - NPG Asia …, 2024 - nature.com
As one of the most intractable neurological diseases, spinal cord injury (SCI) often leads to
permanent neurological impairment in patients. Unfortunately, due to the complex …

Small molecule agonists of cell adhesion molecule L1 mimic L1 functions in vivo

H Kataria, D Lutz, H Chaudhary, M Schachner… - Molecular …, 2016 - Springer
Lack of permissive mechanisms and abundance of inhibitory molecules in the lesioned
central nervous system of adult mammals contribute to the failure of functional recovery after …

Interactions of the mechanosensitive channels with extracellular matrix, integrins, and cytoskeletal network in osmosensation

R Jiao, D Cui, SC Wang, D Li, YF Wang - Frontiers in Molecular …, 2017 - frontiersin.org
Life is maintained in a sea water-like internal environment. The homeostasis of this
environment is dependent on osmosensory system translation of hydromineral information …

The neuroplasticity marker PSA-NCAM: Insights into new therapeutic avenues for promoting neuroregeneration

V Saini, T Kaur, S Kalotra, G Kaur - Pharmacological Research, 2020 - Elsevier
Neuroplastic alterations are the key processes involved in adaptation and rehabilitation after
all neurological injuries and pathologies. Being the central contributor to the developmental …

The L1 cell adhesion molecule affects protein kinase D1 activity in the cerebral cortex in a mouse model of Alzheimer's disease

S Chen, Q Jiang, P Huang, C Hu, H Shen… - Brain research …, 2020 - Elsevier
Alzheimer's disease (AD) is characterized by deposition of β-amyloid protein (Aβ),
neurofibrillary tangles and cognitive deficits resulting from neuronal cell death. In search for …

The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair

V Saini, D Lutz, H Kataria, G Kaur, M Schachner… - Scientific reports, 2016 - nature.com
Polysialic acid (PSA) is a large negatively charged glycan mainly attached to the neural cell
adhesion molecule (NCAM). Several studies have shown that it is important for correct …

Amelioration of the abnormal phenotype of a new L1 syndrome mouse mutation with L1 mimetics

G Loers, D Appel, D Lutz, L Congiu… - The FASEB …, 2021 - Wiley Online Library
L1 syndrome is a rare developmental disorder characterized by hydrocephalus of varying
severity, intellectual deficits, spasticity of the legs, and adducted thumbs. Therapy is limited …