The emerging role of chromatin remodelers in neurodevelopmental disorders: a developmental perspective
B Mossink, M Negwer, D Schubert… - Cellular and Molecular …, 2021 - Springer
Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …
Explainable multi-task learning for multi-modality biological data analysis
Current biotechnologies can simultaneously measure multiple high-dimensional modalities
(eg, RNA, DNA accessibility, and protein) from the same cells. A combination of different …
(eg, RNA, DNA accessibility, and protein) from the same cells. A combination of different …
A multi-encoder variational autoencoder controls multiple transformational features in single-cell image analysis
Image-based cell phenotyping relies on quantitative measurements as encoded
representations of cells; however, defining suitable representations that capture complex …
representations of cells; however, defining suitable representations that capture complex …
The parvalbumin hypothesis of autism spectrum disorder
F Filice, L Janickova, T Henzi, A Bilella… - Frontiers in Cellular …, 2020 - frontiersin.org
The prevalence of autism spectrum disorder (ASD)—a type of neurodevelopmental disorder—
is increasing and is around 2% in North America, Asia, and Europe. Besides the known …
is increasing and is around 2% in North America, Asia, and Europe. Besides the known …
Joint variational autoencoders for multimodal imputation and embedding
Single-cell multimodal datasets have measured various characteristics of individual cells,
enabling a deep understanding of cellular and molecular mechanisms. However …
enabling a deep understanding of cellular and molecular mechanisms. However …
Multimodal charting of molecular and functional cell states via in situ electro-sequencing
Paired mapping of single-cell gene expression and electrophysiology is essential to
understand gene-to-function relationships in electrogenic tissues. Here, we developed in …
understand gene-to-function relationships in electrogenic tissues. Here, we developed in …
[HTML][HTML] Transcriptomic evidence for dense peptidergic networks within forebrains of four widely divergent tetrapods
SJ Smith - Current opinion in neurobiology, 2021 - Elsevier
The primary function common to every neuron is communication with other neurons. Such
cell–cell signaling can take numerous forms, including fast synaptic transmission and slower …
cell–cell signaling can take numerous forms, including fast synaptic transmission and slower …
Predictive and robust gene selection for spatial transcriptomics
A prominent trend in single-cell transcriptomics is providing spatial context alongside a
characterization of each cell's molecular state. This typically requires targeting an a priori …
characterization of each cell's molecular state. This typically requires targeting an a priori …
scPair: Boosting single cell multimodal analysis by leveraging implicit feature selection and single cell atlases
Multimodal single-cell assays profile multiple sets of features in the same cells and are
widely used for identifying and mapping cell states between chromatin and mRNA and …
widely used for identifying and mapping cell states between chromatin and mRNA and …
Learning time-invariant representations for individual neurons from population dynamics
Neurons can display highly variable dynamics. While such variability presumably supports
the wide range of behaviors generated by the organism, their gene expressions are …
the wide range of behaviors generated by the organism, their gene expressions are …