The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

The trifluoromethyl group is found in many synthetic bioactive compounds, and the
difunctionalization of a C C bond, as a powerful strategy for the construction of compounds …

Fluorinated analogues of the canonical α-L-amino acids have gained widespread attention
as building blocks that may endow peptides and proteins with advantageous biophysical …

The elemental characteristics of the fluorine atom tell us that replacing an alkyl chain by a
perfluoroalkyl or polyfluorinated chain in a molecule or polymer is consequential. A brief …

The challenges of the modern society and the growing demand of high-technology sectors
of industrial production bring about a new phase in the development of organic synthesis. A …

Conspectus Deciphering the fluorine code is how we describe not only the focus of this
Account, but also the systematic approach to studying the impact of fluorine's incorporation …

The trifluoromethyl group has gained significance in the pharmaceutical and agrochemical
industries owing to its unique properties.[1, 2] Many trifluoromethylated compounds are …

Conspectus Fluorine is all but absent from biology; however, it has proved to be a
remarkably useful element with which to modulate the activity of biological molecules and to …

This Article describes the development of a decarbonylative Pd-catalyzed aryl–fluoroalkyl
bond-forming reaction that couples fluoroalkylcarboxylic acid-derived electrophiles [RFC (O) …

Perfluorocarbons are primarily characterized by outstanding chemical and biological
inertness, and intense hydrophobic and lipophobic effects. The latter effects provide a …