Tumors are characterized by extracellular matrix (ECM) deposition, remodeling, and cross-
linking that drive fibrosis to stiffen the stroma and promote malignancy. The stiffened stroma …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease characterized by
progressive lung scarring and the histological picture of usual interstitial pneumonia (UIP). It …

Tumor extracellular matrix has been associated with drug resistance and immune
suppression. Here, proteomic and RNA profiling reveal increased collagen levels in lung …

Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary
disease with a median survival of 2–4 years after diagnosis. A significant number of IPF …

Intratumoral fibrosis results from the deposition of a cross-linked collagen matrix by cancer-
associated fibroblasts (CAFs). This type of fibrosis has been shown to exert mechanical …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung
disease (ILD) of unknown aetiology, with a median survival of 2–4 years from the time of …

Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive
fibrosing interstitial pneumonia of unknown cause, occurring primarily in older adults, and …

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR)-dependent pathway is one of the most integral pathways linked to cell …

Abstract Dopamine (DA, 3-hydroxytyramine) is a member of the catecholamine family and is
classically characterized according to its role in the central nervous system as a …

Background Mediastinal lymph node enlargement is prevalent in patients with idiopathic
pulmonary fibrosis (IPF). Studies investigating whether this phenomenon reflects specific …