The RTK interactome: overview and perspective on RTK heterointeractions
MD Paul, K Hristova - Chemical reviews, 2018 - ACS Publications
Receptor tyrosine kinases (RTKs) play important roles in cell growth, motility, differentiation,
and survival. These single-pass membrane proteins are grouped into subfamilies based on …
and survival. These single-pass membrane proteins are grouped into subfamilies based on …
Neurogenesis from neural crest cells: molecular mechanisms in the formation of cranial nerves and ganglia
K Méndez-Maldonado, GA Vega-López… - Frontiers in Cell and …, 2020 - frontiersin.org
The neural crest (NC) is a transient multipotent cell population that originates in the dorsal
neural tube. Cells of the NC are highly migratory, as they travel considerable distances …
neural tube. Cells of the NC are highly migratory, as they travel considerable distances …
Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling
Cellular senescence and the senescence-associated secretory phenotype (SASP) are
implicated in aging and age-related disease, and SASP-related inflammation is thought to …
implicated in aging and age-related disease, and SASP-related inflammation is thought to …
Knockdown of ptk7 reduces the oncogenic potential of breast cancer cells by impeding receptor tyrosine kinase signaling
Protein tyrosine kinase 7 (PTK7), a catalytically defective receptor tyrosine kinase (RTK), is
often upregulated in various cancers. This study aimed to validate PTK7 as a target for …
often upregulated in various cancers. This study aimed to validate PTK7 as a target for …
Wnt signaling in neural crest ontogenesis and oncogenesis
Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a
diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells …
diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells …
PTK7 faces the Wnt in development and disease
H Berger, A Wodarz, A Borchers - Frontiers in Cell and …, 2017 - frontiersin.org
PTK7 (protein tyrosine kinase 7) is an evolutionarily conserved transmembrane receptor
regulating various processes in embryonic development and tissue homeostasis. On a …
regulating various processes in embryonic development and tissue homeostasis. On a …
ROR-family receptor tyrosine kinases
S Stricker, V Rauschenberger, A Schambony - Current topics in …, 2017 - Elsevier
ROR-family receptor tyrosine kinases form a small subfamily of receptor tyrosine kinases
(RTKs), characterized by a conserved, unique domain architecture. ROR RTKs are …
(RTKs), characterized by a conserved, unique domain architecture. ROR RTKs are …
Wnt/planar cell polarity signaling: new opportunities for cancer treatment
Cancer cells are addicted to a large spectrum of extracellular cues implicated in initiation,
stem cell renewal, tumor growth, dissemination in the body, and resistance to treatment …
stem cell renewal, tumor growth, dissemination in the body, and resistance to treatment …
Systematic review of the receptor tyrosine kinase superfamily in neuroblastoma pathophysiology
EJ Rozen, JM Shohet - Cancer and Metastasis Reviews, 2022 - Springer
Background Neuroblastoma is a devastating disease accounting for 15% of all childhood
cancer deaths. Yet, our understanding of key molecular drivers such as receptor tyrosine …
cancer deaths. Yet, our understanding of key molecular drivers such as receptor tyrosine …
The biochemistry, signalling and disease relevance of RYK and other WNT-binding receptor tyrosine kinases
JP Roy, MM Halford, SA Stacker - Growth Factors, 2018 - Taylor & Francis
The receptor tyrosine kinases (RTKs) are a well-characterized family of growth factor
receptors that have central roles in human disease and are frequently therapeutically …
receptors that have central roles in human disease and are frequently therapeutically …