1. Introduction a-Aminoalkylphosphonic acids 1 are structurally analogous to a-amino acids
2, obtained by isosteric substitution of the planar and less bulky carboxylic acid (CO2H) by a …

Nucleoside analogs have been widely used as antiviral, antitumor, and antiparasitic agents
due to their ability to inhibit nucleic acid synthesis. Adenosine, cytidine, guanosine …

As synthetic targets have grown more complex, protection/deprotection protocols have
assumed prominent roles in synthetic organic chemistry. 1–3 The ability to efficiently protect …

This review discusses methods for the metallo-, organo-and biocatalytic asymmetric
synthesis of chiral organophosphorus compounds with many applications in stereoselective …

Cytotoxic deoxynucleoside analogues are widely used in the treatment of haematological
malignancies and solid tumours. Their metabolism and mechanisms of action are relatively …

Benzyl phosphonate esters often serve as reagents in Horner− Wadsworth− Emmons
reactions. In most cases, they can be prepared from benzylic alcohols via formation of the …

The aim of this article is to present an overview of new and useful silicon-based
methodologies valuable for the selective construction of highly functionalized mono-and …

The first total synthesis of caprazamycin A (1), a representative liponucleoside antibiotic, is
described. Diastereoselective aldol reactions of aldehydes 12 and 25–27, derived from …

Rhodium catalyzed O− H insertion reactions employing α-diazophosphonate 20 with
appropriately protected thymidine, uridine, cytosine, adenosine and guanosine derivatives …

Easy PC: α‐Hydroxy phosphonates were synthesized by copper/tert‐butyl hydroperoxide
(TBHP)‐catalyzed oxidative addition reactions of H‐phosphonates with alcohols or ethers …