Keratoconus is a progressive eye disorder primarily affecting individuals in adolescence and
early adulthood. The ectatic changes in the cornea cause thinning and cone-like steepening …

Keratoconus is the most common corneal ectatic disorder. It is characterized by progressive
corneal thinning with resultant irregular astigmatism and myopia. Its prevalence has been …

There is a high demand for developing methods to produce more native-like 3D corneal
structures. In the present study, we produced 3D cornea-mimicking tissues using human …

Regeneration of a severely damaged cornea necessitates the delivery of both epithelium-
renewing limbal epithelial stem cells (LESCs) and stroma-repairing cells, such as human …

Cell therapy has been identified as an effective method to regenerate damaged tissue. Adult
stem cells, also known as somatic stem cells or resident stem cells, are a rare population of …

Ocular stem cell transplantation derived from either autologous or allogeneic donor
corneoscleral junction is a functional cell therapy to manage extensive and/or severe limbal …

Purpose: To report the 3-year clinical outcomes of corneal stromal cell therapy consisting of
the intrastromal implantation with autologous adipose-derived adult stem cells (ADASCs) …

The corneal functions (transparency, refractivity and mechanical strength) deteriorate in
many corneal diseases but can be restored after corneal transplantation (penetrating and …

Adipose-derived stem cells are a subtype of mesenchymal stem cell that offers the important
advantage of being easily obtained (in an autologous manner) from low invasive …

Purpose This phase 1 study seeks to preliminarily evaluate the safety and efficacy of
decellularized human corneal stromal lamina transplantation with or without autologous …