Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …

Thilaganathan and Kalafat Cardiovascular System in Preeclampsia and Beyond 523 age of
60 years have an increased risk of preeclampsia. 18, 31 Previous preeclampsia is a risk …

ESC Guidelines e341 (1) the specific situation of the patient. In this respect, it is specified
that, unless otherwise provided for by national regulations, offlabel use of medication should …

Maternal uterine artery blood flow is critical to maintaining the intrauterine environment,
permitting normal placental function, and supporting fetal growth. It has long been believed …

Pregnancy-induced hypertension (PIH) complicates 6–10% of pregnancies. It is defined as
systolic blood pressure (SBP)> 140 mmHg and diastolic blood pressure (DBP)> 90 mmHg. It …

Objective Cardiac output, a fundamental parameter of cardiovascular function, has
consistently been shown to increase across healthy pregnancy; however, the time course …

The aim of this study was to investigate cardiac functional status in pregnancy using a
comprehensive approach taking into account the simultaneous changes in loading and …

Atrial enlargement in response to pathological stimuli (eg, hypertension, mitral valve
disease) and physiological stimuli (exercise, pregnancy) can be comparable in magnitude …

Cardiac hypertrophy occurs during pregnancy as a consequence of both volume overload
and hormonal changes. Both pregnancy-and exercise-induced cardiac hypertrophy are …

Background—Fingolimod, a sphingosine-1-phosphate receptor agonist, is used for the
treatment of multiple sclerosis and exerts antiapoptotic properties. We hypothesized that …