Abstract G-quadruplexes (G4s) are extremely stable DNA or RNA secondary structures
formed by sequences rich in guanine. These structures are implicated in many essential …

Nucleic acids are excellent at recognizing complementary sequences through the formation
of Watson− Crick base pairs. Since the base pairing enables the highly selective …

G‐quadruplexes are secondary structures formed in G‐rich sequences in DNA and RNA.
Considerable research over the past three decades has led to in‐depth insight into these …

First studies on thrombin-inhibiting DNA aptamers were reported in 1992, and since then a
large number of anticoagulant aptamers has been discovered. TBA–also named HD1, a 15 …

Highly specific and tight-binding nucleic acid aptamers have been selected against a variety
of molecular targets for over 20 years. A significant proportion of these oligonucleotides …

We systematically and quantitatively investigated the structure and thermodynamics of G-
quadruplexes of RNAs and corresponding DNAs of the same sequences under molecular …

G‐quadruplexes have attracted growing interest in recent years due to their occurrence in
vivo and their possible biological functions. In addition to being promising targets for drug …

Abstract G-quadruplexes (G4s), which are known to have important roles in regulation of key
biological processes in both normal and pathological cells, are the most actively studied non …

G-quadruplexes are unusual DNA and RNA secondary structures ubiquitous in a variety of
organisms including vertebrates, plants, viruses and bacteria. The folding topology and …

The thrombin-binding DNA aptamer (TBA) 5′-d (GGTTGGTGTGGTTGG)-3′ forms a G-
quadruplex that is necessary for binding to the coagulation factor thrombin. The stability of …