Retinoic acid receptors: from molecular mechanisms to cancer therapy
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
Retinoids, retinoic acid receptors, and cancer
Retinoids (ie, vitamin A, all-trans retinoic acid, and related signaling molecules) induce the
differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but …
differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but …
GSVA: gene set variation analysis for microarray and RNA-seq data
Background Gene set enrichment (GSE) analysis is a popular framework for condensing
information from gene expression profiles into a pathway or signature summary. The …
information from gene expression profiles into a pathway or signature summary. The …
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
T Schenk, WC Chen, S Göllner, L Howell, L Jin… - Nature medicine, 2012 - nature.com
Acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid
leukemia (AML), characterized by the t (15; 17)-associated PML-RARA fusion, has been …
leukemia (AML), characterized by the t (15; 17)-associated PML-RARA fusion, has been …
The success and the challenge of all-trans retinoic acid in the treatment of cancer
X Ni, G Hu, X Cai - Critical reviews in food science and nutrition, 2019 - Taylor & Francis
All-trans retinoic acid (ATRA), an active metabolite of vitamin A, plays important roles in cell
proliferation, cell differentiation, apoptosis, and embryonic development. The effects of ATRA …
proliferation, cell differentiation, apoptosis, and embryonic development. The effects of ATRA …
Unlocking the potential of retinoic acid in anticancer therapy
All-trans-retinoic acid (ATRA) is a physiologically active metabolite of vitamin A. Its
antitumour activities have been extensively studied in a variety of model systems and clinical …
antitumour activities have been extensively studied in a variety of model systems and clinical …
Differentiation therapy of acute myeloid leukemia: past, present and future
K Petrie, A Zelent, S Waxman - Current opinion in hematology, 2009 - journals.lww.com
Here, we examine the reasons why the exquisite sensitivity of APL to ATRA-based
differentiation therapy has not been extended to other of AML subtypes. Current …
differentiation therapy has not been extended to other of AML subtypes. Current …
Retinoic acid receptors in acute myeloid leukemia therapy
O di Martino, JS Welch - Cancers, 2019 - mdpi.com
Retinoic acid (RA) signaling pathways regulate fundamental biological processes, such as
cell proliferation, development, differentiation, and apoptosis. Retinoid receptors (RARs and …
cell proliferation, development, differentiation, and apoptosis. Retinoid receptors (RARs and …
Clinical responsiveness to all-trans retinoic acid is potentiated by LSD1 inhibition and associated with a quiescent transcriptome in myeloid malignancies
Purpose: In preclinical studies, the lysine-specific histone demethylase 1A (LSD1) inhibitor
tranylcypromine (TCP) combined with all-trans retinoic acid (ATRA) induces differentiation …
tranylcypromine (TCP) combined with all-trans retinoic acid (ATRA) induces differentiation …
Cigarette smoke-induced alterations in blood: A review of research on DNA methylation and gene expression.
Worldwide, smoking remains a threat to public health, causing preventable diseases and
premature mortality. Cigarette smoke is a powerful inducer of DNA methylation and gene …
premature mortality. Cigarette smoke is a powerful inducer of DNA methylation and gene …