The endothelium is a single layer of epithelium covering the surface of the vascular system,
and it represents a physical barrier between the blood and vessel wall that plays an …

Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

NOD-like receptor (NLR), family pyrin domain containing 3 (NLRP3) assembles a protein
complex known as the NLRP3 inflammasome upon sensing certain pathogen products or …

Inflammasomes are a class of cytosolic protein complexes. They act as cytosolic innate
immune signal receptors to sense pathogens and initiate inflammatory responses under …

Vascular endothelium maintains vascular homeostasis through liberating a spectrum of
vasoactive molecules, both protective and harmful regulators of vascular tone, structural …

Atherosclerotic vascular disease and its complications are among the top causes of mortality
worldwide. In the vascular lumen, atherosclerotic plaques are not randomly distributed …

Rationale: Atherosclerotic cardiovascular diseases are the leading cause of mortality
worldwide. Atherosclerotic cardiovascular diseases are considered as chronic inflammation …

Abstract Purpose of the Review In this review, we summarize current insights into the
versatile roles of endothelial cells in atherogenesis. Recent Findings The vascular …

Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and
apoptosis, pyroptosis has unique characteristics in morphology and mechanism …

Sepsis is a multifactorial syndrome primarily determined by the host response to an invading
pathogen. It is common, with over 48 million cases worldwide in 2017, and often lethal. The …