Systemic sclerosis, also called scleroderma, is an immune-mediated rheumatic disease that
is characterised by fibrosis of the skin and internal organs and vasculopathy. Although …

Raynaud phenomenon is a symptom complex caused by impaired digital perfusion and can
occur as a primary phenomenon or secondary to a wide range of underlying causes …

Fibrosis is a pathological process characterized by excessive accumulation of connective
tissue components in an organ or tissue. Fibrosis is produced by deregulated wound …

Christopher P. Denton1, Michael Hughes2, Nataliya Gak1, Josephine Vila3, Maya H. Buch4,
Kuntal Chakravarty1, Kim Fligelstone1, Luke L. Gompels5, Bridget Griffiths3, Ariane L …

Digital ulcers (DUs) are a common visible manifestation of the progressive vascular disease
that characterizes the SSc disease process. DUs not only impact significantly on patients' …

Background In patients with systemic sclerosis (scleroderma, SSc), impaired hand function
greatly contributes to disability and reduced quality of life, and is insufficiently relieved by …

Objective To identify nailfold videocapillaroscopic features and other clinical risk factors for
new digital ulcers (DUs) during a 6‐month period in patients with systemic sclerosis (SSc) …

Objectives The purpose of this study was to assess health-related quality of life (HRQoL)
and disease perception in a large, international group of patients with systemic sclerosis …

Importance Digital ulcers in patients with systemic sclerosis are associated with pain and
poor quality of life. Endothelin-1 promotes vasculopathy in systemic sclerosis after …

Objectives Digital ulcers (DUs) occur in up to half of patients with systemic sclerosis (SSc)
and may lead to infection, gangrene and amputation with functional disability and reduced …