Electrochemical immunosensors developed for amyloid-beta and tau proteins, leading biomarkers of Alzheimer's disease

A Sharma, L Angnes, N Sattarahmady, M Negahdary… - Biosensors, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common neurological disease and a serious cause of
dementia, which constitutes a threat to human health. The clinical evidence has found that …

MicroRNAs in Alzheimer's disease: function and potential applications as diagnostic biomarkers

W Wei, ZY Wang, LN Ma, TT Zhang, Y Cao… - Frontiers in molecular …, 2020 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia. Although the incidence of
AD is high, the rates of diagnosis and treatment are relatively low. Moreover, effective means …

Oligomerization and conformational change turn monomeric β-amyloid and tau proteins toxic: Their role in Alzheimer's pathogenesis

B Penke, M Szűcs, F Bogár - Molecules, 2020 - mdpi.com
The structural polymorphism and the physiological and pathophysiological roles of two
important proteins, β-amyloid (Aβ) and tau, that play a key role in Alzheimer's disease (AD) …

Spontaneous formation of β-sheet nano-barrels during the early aggregation of Alzheimer's amyloid beta

Y Sun, A Kakinen, X Wan, N Moriarty, CPJ Hunt, Y Li… - Nano Today, 2021 - Elsevier
Soluble low-molecular-weight oligomers formed during the early aggregation of amyloid
peptides have been hypothesized as a major toxic species of amyloidogenesis. Herein, we …

The role of glycogen synthase kinase 3 beta in neurodegenerative diseases

H Yu, M Xiong, Z Zhang - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Neurodegenerative diseases (NDDs) pose an increasingly prevalent threat to the well-being
and survival of elderly individuals worldwide. NDDs include Alzheimer's disease (AD) …

New pathways identify novel drug targets for the prevention and treatment of Alzheimer's disease

B Penke, M Szűcs, F Bogár - International Journal of Molecular Sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disorder. AD is a
complex and multifactorial disease that is responsible for 60–80% of dementia cases. Aging …

DHA ameliorates cognitive ability, reduces amyloid deposition, and nerve fiber production in Alzheimer's disease

M Xiao, W Xiang, Y Chen, N Peng, X Du, S Lu… - Frontiers in …, 2022 - frontiersin.org
Background The etiology of Alzheimer's disease (AD) is very complex. Docosahexaenoic
acid (DHA) is important in cognitive ability and nervous system development. A limited …

Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease

M Wei, T Wu, N Chen - Ageing Research Reviews, 2024 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder. As the demographic shifting
towards an aging population, AD has emerged as a prominent public health concern. The …

Recent advances in demystifying o‐glycosylation in health and disease

J Li, B Guo, W Zhang, S Yue, S Huang, S Gao… - …, 2022 - Wiley Online Library
O‐Glycosylation is one of the most common protein post‐translational modifications (PTM)
and plays an essential role in the pathophysiology of diseases. However, the complexity of …

Intracerebral seeding of amyloid-β and tau pathology in mice: Factors underlying prion-like spreading and comparisons with α-synuclein

BB McAllister, SG Lacoursiere, RJ Sutherland… - Neuroscience & …, 2020 - Elsevier
Alzheimer's disease (AD) is characterized neuropathologically by progressive
neurodegeneration and by the presence of amyloid plaques and neurofibrillary tangles …