Biomarker discovery and validation are necessary for improving the prediction of clinical
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …

Epilepsy is a neurological disorder afflicting~ 65 million people worldwide. It is caused by
aberrant synchronized firing of populations of neurons primarily due to imbalance between …

Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …

Epilepsy is a group of chronic neurological disorders characterized by recurrent,
spontaneous, and unpredictable seizures. It is one of the most common neurological …

Brain inflammation is one of the main causes of epileptogenesis, a chronic process triggered
by various insults, including genetic or acquired factors that enhance susceptibility to …

Epigenetic modifications are emerging as major players in the pathogenesis of
neurodegenerative disorders and susceptibility to acute brain injury. DNA and histone …

Epigenetic mechanisms, such as alterations in histone acetylation based on histone
deacetylases (HDACs) activity, have been linked not only to normal brain function but also to …

Adenosine is an endogenous anticonvulsant and neuroprotectant of the brain. Seizure
activity produces large quantities of adenosine, and it is this seizure-induced adenosine …

The zebrafish has become an excellent model for the study of human diseases because it
offers many advantages over other vertebrate animal models. The pineal gland, as well as …

Epilepsy is a chronic brain disease characterized by recurrent seizures. Circular RNA
(circRNA) is a novel family of endogenous non‐coding RNAs that have been proposed to …