Polymeric nanoparticle vaccines to combat emerging and pandemic threats

D Wibowo, SHT Jorritsma, ZJ Gonzaga, B Evert… - Biomaterials, 2021 - Elsevier
Subunit vaccines are more advantageous than live attenuated vaccines in terms of safety
and scale-up manufacture. However, this often comes as a trade-off to their efficacy. Over …

Polymeric nanoparticles for targeted treatment in oncology: current insights

RH Prabhu, VB Patravale, MD Joshi - International journal of …, 2015 - Taylor & Francis
Chemotherapy, a major strategy for cancer treatment, lacks the specificity to localize the
cancer therapeutics in the tumor site, thereby affecting normal healthy tissues and …

Polymerization-induced self-assembly of block copolymer nano-objects via RAFT aqueous dispersion polymerization

NJ Warren, SP Armes - Journal of the American Chemical Society, 2014 - ACS Publications
In this Perspective, we discuss the recent development of polymerization-induced self-
assembly mediated by reversible addition–fragmentation chain transfer (RAFT) aqueous …

Stimuli-responsive polymersomes for biomedical applications

X Hu, Y Zhang, Z Xie, X Jing, A Bellotti, Z Gu - Biomacromolecules, 2017 - ACS Publications
Polymersomes, the structural analogues of liposomes, are hollow structures enclosed by a
bilayer membrane made from amphiphilic copolymers. Polymersomes have been proposed …

50th Anniversary Perspective: Functional Nanoparticles from the Solution Self-Assembly of Block Copolymers

U Tritschler, S Pearce, J Gwyther, GR Whittell… - …, 2017 - ACS Publications
This Perspective outlines recent advances concerning the formation and potential uses of
block copolymer micelles, a class of soft-matter-based nanoparticles of growing importance …

Dysregulated pH: a perfect storm for cancer progression

BA Webb, M Chimenti, MP Jacobson… - Nature Reviews Cancer, 2011 - nature.com
Although cancer is a diverse set of diseases, cancer cells share a number of adaptive
hallmarks. Dysregulated pH is emerging as a hallmark of cancer because cancers show …

Strategies in the design of nanoparticles for therapeutic applications

RA Petros, JM DeSimone - Nature reviews Drug discovery, 2010 - nature.com
Engineered nanoparticles have the potential to revolutionize the diagnosis and treatment of
many diseases; for example, by allowing the targeted delivery of a drug to particular subsets …

Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: concepts and applications

E Fleige, MA Quadir, R Haag - Advanced drug delivery reviews, 2012 - Elsevier
The use of polymeric nanocarriers to transport active compounds like small-molecular drugs,
peptides, or genes found an increased attention throughout the different fields of natural …

Nanostructured carriers as innovative tools for cancer diagnosis and therapy

C Martinelli, C Pucci, G Ciofani - APL bioengineering, 2019 - pubs.aip.org
Cancer accounts for millions of deaths every year and, due to the increase and aging of the
world population, the number of new diagnosed cases is continuously rising. Although many …

Endocytosis at the nanoscale

I Canton, G Battaglia - Chemical Society Reviews, 2012 - pubs.rsc.org
Endocytosis is a fundamental process in which eukaryotic cells internalise molecules and
macromolecules via deformation of the membrane and generation of membrane-bound …