The GBA gene encodes for the lysosomal enzyme glucocerebrosidase (GCase), which
maintains glycosphingolipid homeostasis. Approximately 5–15% of PD patients have …

Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …

About 15% of patients with Parkinson disease (PD) have family history and 5–10% have a
monogenic form of the disease with Mendelian inheritance. To date, at least 23 loci and 19 …

Gaucher disease (GD, ORPHA355) is a rare, autosomal recessive genetic disorder. It is
caused by a deficiency of the lysosomal enzyme, glucocerebrosidase, which leads to an …

Parkinson's disease (PD) is the second most common degenerative disorder. Although the
disease was described more than 200 years ago, its pathogenetic mechanisms have not yet …

While mitochondrial dysfunction is emerging as key in Parkinson's disease (PD), a central
question remains whether mitochondria are actual disease drivers and whether boosting …

Parkinson's disease (PD) is the second most common neurodegenerative disorder and the
fastest growing neurologic disease in the world, yet no disease-modifying therapy is …

Abstract Parkinson's disease (PD), known as one of the most universal neurodegenerative
diseases, is a serious threat to the health of the elderly. The current treatment has been …

Parkinson's Disease (PD) is the second most common neurodegenerative disorder. Clinical
approaches to manage PD include symptomatic therapies, serving to compensate for the …

In eukaryotic cells, the endoplasmic reticulum (ER) is the cell compartment involved in
secretory protein translocation and quality control of secretory protein folding. Different …