Genome-wide panels of SNPs have recently been used in domestic animal species to map
and identify genes for many traits and to select genetically desirable livestock. This has led …

Domesticated plants have long served as excellent models for studying evolution. Many
genes and mutations underlying important domestication traits have been identified, and …

Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers. We
performed exome sequencing on 113 tumor-normal pairs, yielding a mean of 82 non-silent …

Abstract Background The international Dog10K project aims to sequence and analyze
several thousand canine genomes. Incorporating 20× data from 1987 individuals, including …

The dog was the first domesticated animal but it remains uncertain when the domestication
process began and whether it occurred just once or multiple times across the Northern …

Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body
size than any other terrestrial mammal. Here, we generate a high density map of canine …

With several hundred genetic diseases and an advantageous genome structure, dogs are
ideal for mapping genes that cause disease. Here we report the development of a …

Copy number variations (CNVs) affect a wide range of phenotypic traits; however, CNVs in
or near segmental duplication regions are often intractable. Using a read depth approach …

The United Kingdom pedigree-dog industry has faced criticism because certain aspects of
dog conformation stipulated in the UK Kennel Club breed standards have a detrimental …

Retrotransposition of processed mRNAs is a common source of novel sequence acquired
during the evolution of genomes. Although the vast majority of retroposed gene copies, or …