Increased glucose metabolism and uptake are characteristic of many tumors and used
clinically to diagnose and monitor cancer progression. In addition to cancer cells, the tumor …

Metabolic programming in the tumor microenvironment (TME) alters tumor immunity and
immunotherapeutic response in tumor-bearing mice and patients with cancer. Here, we …

Metabolic reprogramming is a hallmark of cancer and allows tumour cells to meet the
increased energy demands required for rapid proliferation, invasion, and metastasis …

Background Immune checkpoint blockade resistance narrows the efficacy of cancer
immunotherapies, but the underlying mechanism remains elusive. Delineating the inherent …

Chimeric antigen receptor (CAR) T cells have achieved true clinical success in treating
hematological malignancy patients, laying the foundation of CAR T cells as a new pillar of …

Availability of the essential amino acid methionine affects cellular metabolism and growth,
and dietary methionine restriction has been implicated as a cancer therapeutic strategy …

Although Warburg's discovery of intensive glucose uptake by tumors, followed by lactate
fermentation in oxygen presence of oxygen was made a century ago, it is still an area of …

Immunosuppression is a hallmark of pancreatic ductal adenocarcinoma (PDAC),
contributing to early metastasis and poor patient survival. Compared to the localized tumors …

Abstract Background Circular RNAs (circRNAs) have important regulatory functions in
cancer, but the role of circRNAs in the tumor microenvironment (TME) remains unclear …

Lysine lactylation (Kla) has recently been reported to participate in regulating transcription in
human cells. However, the characterization, regulatory mechanism and functional …